Results from the RECOVERY trial and the PRINCIPLE trial have shown no significant clinical benefit of
· oral or intravenous azithromycin in patients hospitalised with COVID-19
· oral azithromycin in patients with early stages of COVID-19 managed at home
Results from the PRINCIPLE trial have additionally shown there is no significant clinical benefit of oral doxycycline in patients with early stages of COVID-19 managed at home.
Within primary care it is recommended azithromycin or doxycycline should NOT be used in the primary management of COVID-19 infection.